Acute kidney injury caused by high dose methotrexate is a severe and fatal toxicity. Carboxypeptidase is an fda-approved drug used to treat kidney dysfunction caused by high doses of methotrexate.
Ultragenyx Pharmaceutical approved Mepsevii (vestronidase alfa-vjbk) to treat mucosaccharide storage syndrome (MPS VII), also known as Sly syndrome, in children and adults.
The us food and drug administration has approved its drug to treat secondary hyperparathyroidism in patients with chronic kidney disease, amgen said on February 7, 2017.